Journal article
The role of circadian clock pathways in viral replication
- Abstract:
- The daily oscillations of bi ological and behavioural processes are controlled by the circadian clock circuitry that drives the physiology of the organism and, in particular, the functioning of the immune system in response to infectious agents. Circadian rhythmicity is known to affect both the pharmacokinetics and pharmacodynamics of pharmacological agents and vaccine-elicited immune responses. A better understanding of the role circadian pathways play in the regulation of virus replication will impact our clinical management of these diseases. This review summarises the experimental and clinical evidence on the interplay between different viral pathogens and our biological clocks, emphasising the importance of continuing research on the role played by the biological clock in virus-host organism interaction.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 576.1KB, Terms of use)
-
- Publisher copy:
- 10.1007/s00281-021-00908-2
Authors
- Publisher:
- Springer
- Journal:
- Seminars in Immunopathology More from this journal
- Volume:
- 44
- Issue:
- 2
- Pages:
- 175–182
- Publication date:
- 2022-02-22
- Acceptance date:
- 2021-12-26
- DOI:
- EISSN:
-
1863-2300
- ISSN:
-
1863-2297
- Language:
-
English
- Keywords:
- Pubs id:
-
1234382
- Local pid:
-
pubs:1234382
- Deposit date:
-
2022-01-27
- ARK identifier:
Terms of use
- Copyright holder:
- Zhuang et al.
- Copyright date:
- 2022
- Rights statement:
- © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer at: https://doi.org/10.1007/s00281-021-00908-2
If you are the owner of this record, you can report an update to it here: Report update to this record