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Journal article

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.

Abstract:
Regulation of the hypoxic response in humans is regulated by the post-translational hydroxylation of hypoxia inducible transcription factor; a recombinant form of a human prolyl-4-hydroxylase (PHD2) was characterised and shown to have an unexpectedly high affinity for, and to copurify with endogenous levels of, its Fe(ii) cofactor and 2-oxoglutarate cosubstrate.
Publication status:
Published

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Publisher copy:
10.1039/b511249b

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Journal:
Molecular bioSystems
Volume:
1
Issue:
4
Pages:
321-324
Publication date:
2005-10-05
DOI:
EISSN:
1742-2051
ISSN:
1742-206X
URN:
uuid:7d07c06f-922e-4b92-86e7-d67ea3ffd414
Source identifiers:
33567
Local pid:
pubs:33567

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