Axon bundle spacing in the anterior cingulate cortex of the human brain.

Journal article

The anterior cingulate cortex (ACC) is implicated in neuropsychiatric disorders. Post-mortem axon bundle data will be important to complement novel MRI methods for analysing cortical diffusion data. [Jespersen SN, Kroenke CD, Ostergaard L, et al. Modeling dendrite density from magnetic resonance diffusion measurements. Neuroimage. 2007;34:1473-86] Therefore we aimed to assess perimeter, area, density and spacing of axon bundles in BA24 not previously measured in the human ACC using image analysis of 10 microm-thick tangential sections of layer IV in 4 normal patients. Axon bundle mean perimeter was 53.8 microm, mean area was 197.1 microm(2), mean density was 226.3/mm(2), and mean spacing was 73.8 microm. Thus, axon bundles were widely spaced relative to cell body minicolumns and other prelimbic areas. A review of the literature suggests that there is hierarchical regional variation of bundle and column spacing.

Authors: Di Rosa, E; Crow, T; Chance, SA

• Publication status: Published
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
• Volume: 15
• Issue: 12
• Pages: 1389-1392
• Publication date: 2008-12-01
• DOI: 10.1016/j.jocn.2008.01.018
• EISSN: 1532-2653
• ISSN: 0967-5868
• Language: English
• Keywords: Magnetic Resonance Imaging; Female; Humans; Axons; Brain Mapping; Gyrus Cinguli; Aged, 80 and over; Male; Postmortem Changes; Neuroglia