Journal article
Using Laponite to deliver BMP‐2 for bone tissue engineering – in vitro, chorioallantoic membrane assay and murine subcutaneous model validation
- Abstract:
- Fracture non-union occurs due to various factors, leading to the development of potentially substantial bone defects. While autograft and allograft are the current gold standards for non-union fractures, challenges related to availability and immune rejection highlight the need for improved treatments. A strategy in bone tissue engineering is to harness growth factors to induce an effect on cells to change their phenotype, behavior and initiate signaling pathways which lead to increased matrix deposition and tissue formation. Bone morphogenetic protein-2 (BMP-2) is a potent osteogenic growth factor however, given its rapid clearance time in vivo, there is a specific therapeutic window for efficacy while avoiding potential deleterious side-effects. It is demonstrated that a Laponite nanoclay coating on a 3D printable and bioresorbable poly(caprolactone) trimethacrylate-based resin enables binding of BMP-2, decreases the rate of release, enabling reduced concentrations to be used while enhancing osteoinduction in both in vitro and in vivo models.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 7.3MB, Terms of use)
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- Publisher copy:
- 10.1002/admi.202400332
Authors
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/R015651/1
+ UK Research and Innovation
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- Funder identifier:
- https://ror.org/001aqnf71
- Grant:
- EP/X027163/1
+ Biotechnology and Biological Sciences Research Council
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- Funder identifier:
- https://ror.org/00cwqg982
- Grant:
- BB/R015651/1
- Publisher:
- Wiley
- Journal:
- Advanced Materials Interfaces More from this journal
- Volume:
- 11
- Issue:
- 29
- Article number:
- 2400332
- Publication date:
- 2024-07-29
- Acceptance date:
- 2024-07-16
- DOI:
- EISSN:
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2196-7350
- Language:
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English
- Keywords:
- Pubs id:
-
2022662
- Local pid:
-
pubs:2022662
- Deposit date:
-
2025-07-04
- ARK identifier:
Terms of use
- Copyright holder:
- Marshall et al
- Copyright date:
- 2024
- Rights statement:
- © 2024 The Author(s). Advanced Materials Interfaces published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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