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From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

Abstract:

Understanding the basic biology of human ageing is a key milestone in attempting to ameliorate the deleterious consequences of old age. This is an urgent research priority given the global demographic shift towards an ageing population. Although some molecular pathways that have been proposed to contribute to ageing have been discovered using classical biochemistry and genetics, the complex, polygenic and stochastic nature of ageing is such that the process as a whole is not immediately amena...

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Publication status:
Published

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Publisher copy:
10.1007/s00018-007-7123-x

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Faragher, RG More by this author
Journal:
Cellular and molecular life sciences : CMLS
Volume:
64
Issue:
19-20
Pages:
2620-2641
Publication date:
2007-10-05
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
URN:
uuid:7c945f23-bdd0-4ab4-b3c0-c5ac1e1652ab
Source identifiers:
100342
Local pid:
pubs:100342

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