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Journal article

Sickle-cell disease.

Abstract:

Sickle-cell disease is one of the most common severe monogenic disorders in the world. Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to the pathophysiology of this disease, although the importance of chronic anaemia, haemolysis, and vasculopathy has been established. Clinical management is basic and few treatments have a robust evidence base. One of the main problems of sickle-cell disease in children is the development of cerebrovascular disease a...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
Journal:
Lancet
Volume:
376
Issue:
9757
Pages:
2018-2031
Publication date:
2010-12-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:7c91b08d-9da3-4831-973b-1eda1fdba4db
Source identifiers:
110373
Local pid:
pubs:110373

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