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Journal article

Model-driven experimentation: A new approach to understand mechanisms of tertiary lymphoid tissue formation, function, and therapeutic resolution

Abstract:

The molecular and cellular processes driving the formation of secondary lymphoid tissues have been extensively studied using a combination of mouse knockouts, lineage-specific reporter mice, gene expression analysis, immunohistochemistry, and flow cytometry. However, the mechanisms driving the formation and function of tertiary lymphoid tissue (TLT) experimental techniques have proven to be more enigmatic and controversial due to differences between experimental models and human disease patho...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2016.00658

Authors


Butler, JA More by this author
Cosgrove, J More by this author
More by this author
ORCID:
0000-0003-4411-1776
More by this author
ORCID:
0000-0003-1055-0471
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
7
Issue:
APR
Pages:
658
Publication date:
2017-04-04
Acceptance date:
2016-12-16
DOI:
EISSN:
1664-3224
Pubs id:
pubs:821758
URN:
uri:7c8c2c2d-6cb7-4433-828b-b40e6a40bbca
UUID:
uuid:7c8c2c2d-6cb7-4433-828b-b40e6a40bbca
Local pid:
pubs:821758

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