Total synthesis of antascomicin B.
- (Chemical Equation Presented) The structurally enticing antascomicin B (1), which exhibits potent immunosuppressant-antagonizing properties, has a complex polyketide structure. Key steps in its enantioselective total synthesis include a transannular catechol-templated Dieckmann reaction to assemble the challenging tricarbonyl functionality and a butanediacetal-directed allylation. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA.
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