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Total synthesis of antascomicin B.

Abstract:
(Chemical Equation Presented) The structurally enticing antascomicin B (1), which exhibits potent immunosuppressant-antagonizing properties, has a complex polyketide structure. Key steps in its enantioselective total synthesis include a transannular catechol-templated Dieckmann reaction to assemble the challenging tricarbonyl functionality and a butanediacetal-directed allylation. © 2005 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/anie.200500174

Authors


Brittain, DE More by this author
Griffiths-Jones, CM More by this author
Linder, MR More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
McCusker, C More by this author
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Journal:
Angewandte Chemie (International ed. in English)
Volume:
44
Issue:
18
Pages:
2732-2737
Publication date:
2005-04-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:7c638b51-c3fb-4920-94b3-d5868bc5240b
Source identifiers:
58747
Local pid:
pubs:58747
Language:
English
Keywords:

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