Journal article
Two interlinked bistable switches govern mitotic control in mammalian cells
- Abstract:
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Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, has been proposed to generate different thresholds for transitions between these cell-cycle states [3, 4, 5]. Recently, the activity of the major Cdk1-counteracting phosphatase, PP2A:B55, has also been found to be bistable due to Greatwall kinase-dependent regulation [6]. However, the interplay of the reg...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 4.9MB, Terms of use)
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- Publisher copy:
- 10.1016/j.cub.2018.09.059
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
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Grant:
LoLagrant(BB/M00354X/1)toB.N.
H.H
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Current Biology More from this journal
- Volume:
- 28
- Issue:
- 23
- Pages:
- 3824-3832
- Publication date:
- 2018-11-15
- Acceptance date:
- 2018-09-26
- DOI:
- EISSN:
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1879-0445
- ISSN:
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0960-9822
- Pmid:
-
30449668
Item Description
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:949065
- UUID:
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uuid:7c250739-6d18-4bf9-bfb9-9ed552d08c62
- Local pid:
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pubs:949065
- Source identifiers:
-
949065
- Deposit date:
-
2018-12-03
Terms of use
- Copyright holder:
- Rata et al
- Copyright date:
- 2018
- Notes:
-
Copyright 2018 The Authors. Published by Elsevier Ltd.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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