Journal article icon

Journal article

Two interlinked bistable switches govern mitotic control in mammalian cells

Abstract:

Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, has been proposed to generate different thresholds for transitions between these cell-cycle states [3, 4, 5]. Recently, the activity of the major Cdk1-counteracting phosphatase, PP2A:B55, has also been found to be bistable due to Greatwall kinase-dependent regulation [6]. However, the interplay of the reg...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.cub.2018.09.059

Authors


Suarez Peredo Rodriguez, MF More by this author
Echegaray Iturra, F More by this author
Expand authors...
Publisher:
Cell Press Publisher's website
Journal:
Current Biology Journal website
Volume:
28
Issue:
23
Pages:
3824-3832
Publication date:
2018-11-15
Acceptance date:
2018-09-26
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Pubs id:
pubs:949065
URN:
uri:7c250739-6d18-4bf9-bfb9-9ed552d08c62
UUID:
uuid:7c250739-6d18-4bf9-bfb9-9ed552d08c62
Local pid:
pubs:949065

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP