Journal article
Probing the dynamics of complexed local anesthetics via neutron scattering spectroscopy and DFT calculations
- Abstract:
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Since potential changes in the dynamics and mobility of drugs upon complexation for delivery may affect their ultimate efficacy, we have investigated the dynamics of two local anesthetic molecules, bupivacaine (BVC, C18H28N2O) and ropivacaine (RVC, C17H26N2O), in both their crystalline forms and complexed with water-soluble oligosaccharide 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). The study was carried out by neutron scattering spectroscopy, along with thermal analysis, and density functional...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 960.8KB, Terms of use)
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- Publisher copy:
- 10.1016/j.ijpharm.2017.03.051
Authors
Funding
+ Institute Laue-von-Langevin
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Funding agency for:
Jacobsen, H
Grant:
*Grant Number Example*
+ Science without Borders Program
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Funding agency for:
Martins, M
Grant:
205609/2014-7
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- International journal of pharmaceutics More from this journal
- Volume:
- 524
- Issue:
- 1-2
- Pages:
- 397-406
- Publication date:
- 2017-03-31
- Acceptance date:
- 2017-03-23
- DOI:
- EISSN:
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1873-3476
- ISSN:
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0378-5173
- Pmid:
-
28366805
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:687963
- UUID:
-
uuid:7bd4cb43-b8d8-4a0f-ad25-e624d14edb12
- Local pid:
-
pubs:687963
- Source identifiers:
-
687963
- Deposit date:
-
2018-05-11
Terms of use
- Copyright holder:
- © 2017 Elsevier BV All rights reserved
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Elsevier at: 10.1016/j.ijpharm.2017.03.051
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