Journal article
Revisiting the effect of acute P. falciparum malaria on Epstein-Barr virus: host balance in the setting of reduced malaria endemicity.
- Abstract:
-
Burkitt's lymphoma (BL), an EBV-associated tumour, occurs at high incidence in populations where malaria is holoendemic. Previous studies in one such population suggested that acute P.falciparum infection impairs EBV-specific T-cell surveillance, allowing expansion of EBV infected B-cells from which BL derives. We re-examined the situation in the same area, The Gambia, after a reduction in malaria endemicity. Cellular immune responses to EBV were measured in children with uncomplicated malari...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 375.7KB)
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- Publisher copy:
- 10.1371/journal.pone.0031142
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Authors
Funding
Medical Research Council, Gambia
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 7
- Issue:
- 2
- Article number:
- e31142
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
-
1932-6203
- ISSN:
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1932-6203
- Source identifiers:
-
313005
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:7bbca72b-9639-4984-901f-68d494b43940
- Local pid:
- pubs:313005
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Jayasooriya et al
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Jayasooriya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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