Composite adenocarcinoma and large cell neuroendocrine carcinoma of the rectum.

Journal article

Composite glandular-endocrine tumors of the gastrointestinal tract are rare neoplasms. Even more uncommon are the so-called amphicrine tumors, lesions in which dual epithelial and endocrine differentiation occurs in the same cell. We describe a patient who complained of rectal pain and bleeding with a mixed or composite adenocarcinoma and neuroendocrine carcinoma of the rectum. Histological examination revealed a distinct adenocarcinoma of conventional type with glandular structures admixed intimately with a neuroendocrine carcinoma. The latter component was deeply infiltrative, while the adenocarcinoma occupied the more superficial aspect of the tumor. What was interesting was the immunophenotype of the lesion: cytokeratin (CK) 20 expression was very focal in the adenocarcinoma component and negative in the neuroendocrine carcinoma, while CK 7 was expressed strongly in the adenocarcinoma and only focally in the neuroendocrine component. This cytokeratin profile suggests a possible origin from the anal transitional zone.

Authors: Makino, A; Serra, S; Chetty, R

• Publication status: Published
• Journal: Virchows Archiv : an international journal of pathology
• Volume: 448
• Issue: 5
• Pages: 644-647
• Publication date: 2006-05-01
• DOI: 10.1007/s00428-006-0169-6
• EISSN: 1432-2307
• ISSN: 0945-6317
• Language: English
• Keywords: Carcinoma, Large Cell; Adenocarcinoma; Rectal Neoplasms; Neoplasms, Multiple Primary; Female; Immunohistochemistry; Carcinoma, Neuroendocrine; Aged, 80 and over; Humans