Inhibition of HIV replication by amino-sugar derivatives.

Journal article

The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120-8124; (1987) Nature 330, 74-77; (1987) Lancet i, 1025-1026]. They are thought to act by inhibiting alpha-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of HIV cytopathicity. Several alpha-glucosidase inhibitors and alpha-fucosidase inhibitors were found to be active at concentrations which were non-cytotoxic.

Authors: Fleet, G; Karpas, A; Dwek, R; Fellows, L; Tyms, A

• Publication status: Published
• Journal: FEBS letters
• Volume: 237
• Issue: 1-2
• Pages: 128-132
• Publication date: 1988-09-01
• DOI: 10.1016/0014-5793(88)80185-6
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: HIV-2; DNA Replication; HIV-1; Humans; Cell Line; Virus Replication; Molecular Structure; Structure-Activity Relationship; Amino Sugars; HIV