High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival.

Journal article

SH2-containing 5'-inositol phosphatase (SHIP2) is a known regulator of insulin function. Genetic knockout of SHIP2 in mice causes mild insulin hypersensitivity and prevents high-fat-diet-induced obesity. SHIP2 also regulates actin remodeling and epidermal growth factor receptor (EGFR) turnover and supports breast cancer; and metastatic growth. To determine the clinical significance of SHIP2 expression in breast cancer and its relationship to relevant oncogenic molecules, SHIP2 expression was ...

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Authors: Prasad, N; Tandon, M; Handa, A; Moore, G; Babbs, C

• Publication status: Published
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
• Volume: 29
• Issue: 5
• Pages: 330-341
• Publication date: 2008-01-01
• DOI: 10.1159/000172970
• EISSN: 1423-0380
• ISSN: 1010-4283
• Language: English
• Keywords: PTEN Phosphohydrolase; Survival Rate; Immunoenzyme Techniques; Female; Adult; Middle Aged; Prognosis; Blotting, Western; Aged, 80 and over; Carcinoma, Intraductal, Noninfiltrating; src Homology Domains; Phosphoric Monoester Hydrolases; Aged; Humans; Case-Control Studies; Tumor Markers, Biological; Breast Neoplasms; Neoplasm Invasiveness; Carcinoma, Ductal, Breast