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Hyaluronan in the lymphatics: The key role of the hyaluronan receptor LYVE-1 in leucocyte trafficking

Abstract:

LYVE-1, a close relative of the leucocyte receptor, CD44, is the main receptor for hyaluronan (HA) in lymphatic vessel endothelium and a widely used marker for distinguishing between blood and lymphatic vessels. Enigmatic for many years because of its anomalous HA-binding characteristics, the function of LYVE-1 has just recently been identified as that of a lymphatic docking receptor for dendritic cells, selectively engaging with their surface HA glycocalyx to regulate entry to peripheral lym...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.matbio.2018.02.001

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
Role:
Author
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Grant:
G1100134
MR/L008610/1
MC_UU_12010/2
Publisher:
Elsevier Publisher's website
Journal:
Matrix Biology Journal website
Volume:
78-79
Pages:
219-235
Publication date:
2018-02-06
Acceptance date:
2018-02-01
DOI:
EISSN:
1569-1802
ISSN:
0945-053X
Pubs id:
pubs:824247
URN:
uri:7b740e02-bcac-416e-8c67-2834a8f85a6a
UUID:
uuid:7b740e02-bcac-416e-8c67-2834a8f85a6a
Local pid:
pubs:824247

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