New transition metal ion complexes with benzimidazole-5-carboxylic acid hydrazides with antitumor activity.

Journal article

Metal complexes of 2-methyl-1H-benzimidazole-5-carboxylic acid hydrazide (4a; L(1)) and its Schiff base 2-methyl-N-(propan-2-ylidene)-1H-benzimidazole-5-carbohydrazide (5a; L(2)) with transition metal ions e.g., copper, silver, nickel, iron and manganese were prepared. The complexes formed were 1:1 or 1:2 M:L complexes and have the structural formulae [Cu(L(1))Cl(H(2)O)]Cl x 3 H(2)O (6), [Ag(L(1))NO(3)(H(2)O)] (7), [Ni(L(1))Cl(2)(H(2)O)(2)] x H(2)O (8), [Fe(L(1))Cl(3)(H(2)O)] x 3 H(2)O (9) and [Mn(L(1))(2)Cl(H(2)O)]Cl x 3 H(2)O (10) for ligand L(1), and [Cu(L(2))Cl(2)(H(2)O)(2)] x H(2)O (11), [Ag(L(2))(2)]NO(3) x H(2)O (12), [Ni(L(2))(2)Cl(2)] x 5 H(2)O (13), [Fe(L(2))(2)Cl(2)]Cl x 2 H(2)O (14) and [Mn(L(2))Cl(2)(H(2)O)(2)] x H(2)O (15) for ligand L(2). The antitumor activity of the synthesized compounds has been studied. The silver complex 7 was found to display cytotoxicity (IC(50)=2 microM) against both human lung cancer cell line A549 and human breast cancer cell line MCF-7.

Authors: Galal, SA; Hegab, K; Kassab, A; Rodriguez, M; Kerwin, S

• Publication status: Published
• Journal: European journal of medicinal chemistry
• Volume: 44
• Issue: 4
• Pages: 1500-1508
• Publication date: 2009-04-01
• DOI: 10.1016/j.ejmech.2008.07.013
• EISSN: 1768-3254
• ISSN: 0223-5234
• Language: English
• Keywords: Benzimidazoles; Drug Design; Inhibitory Concentration 50; Hydrazines; Antineoplastic Agents; Organometallic Compounds; Humans; Cell Line, Tumor; Transition Elements