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A systematic literature review of microscopy methods reported in malaria clinical trials

Abstract:
Microscopy of stained blood films is essential for the diagnosis of malaria, differentiation of parasite species, and estimation of parasite density performed for assessments of antimalarial drug efficacy. The accuracy and comparability of these measures over time and space are vital to discern the emergence or spread of antimalarial drug resistance. Although evidence-based guidelines for malaria microscopy methods exist, the age-old microscopy techniques for parasitological assessments are subject to considerable methodological variations. The purpose of this review was to explore critically how microscopy methods were reported in published malarial studies between 2013 and 2017 with the focus on outlining the methodological differences and improving reporting standards in practice.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4269/ajtmh.20-1219

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0002-2158-846X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-7849-3293


Publisher:
American Society of Tropical Medicine and Hygiene
Journal:
American Journal of Tropical Medicine and Hygiene More from this journal
Volume:
104
Issue:
3
Pages:
836-841
Publication date:
2020-12-21
Acceptance date:
2020-10-21
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
Pmid:
33350371


Language:
English
Keywords:
Pubs id:
1151335
Local pid:
pubs:1151335
Deposit date:
2021-07-21

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