Journal article icon

Journal article

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

Abstract:

Using chemical germ-line mutagenesis, we screened mice for defects in the humoral immune response to a type II T-independent immunogen and an experimental alphavirus vector. A total of 26 mutations that impair humoral immunity were recovered, and 19 of these mutations have been positionally cloned. Among the phenovariants were bumble, cellophane, and Worker ascribed to mutations in Nfkbid, Zeb1, and Ruvbl2, respectively. We show that IκBNS, the nuclear IκB-like protein encoded by Nfkbid, is r...

Expand abstract

Actions


Access Document


Publisher copy:
10.1073/pnas.1209134109

Authors


Arnold, CN More by this author
Dosenovic, P More by this author
McInerney, GM More by this author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
31
Pages:
12286-12293
Publication date:
2012-07-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:7b2eaf90-e82d-4901-b28f-ed21718ff3a5
Source identifiers:
418815
Local pid:
pubs:418815

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP