Journal article

Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya

Abstract:: We performed a countrywide assessment of HIV drug resistance among 123 patients with virological failure on second-line antiretroviral therapy (ART) in Kenya. The percentage of patients harbouring intermediate-to-high-level resistance was 27% for lopinavir-ritonavir, 24% for atazanavir-ritonavir and 7% for darunavir-ritonavir, and 25% had complete loss of activity to all available first and secondline drugs. Overall, one in four patients failing second-line ART have completely exhausted available antiretrovirals in Kenya, highlighting the need for increased access to third-line drugs.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Inzaule, S., Hamers, R., Mukui, I., Were, K., Owiti, P., Kwaro, D., de Wit, T., & Zeh, C. (2017). Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya. AIDS, 31(10), 1495–1498.

MLA Style

Inzaule, S, et al. “Emergence of Untreatable, Multidrug-Resistant HIV-1 in Patients Failing Second-Line Therapy in Kenya.” AIDS, vol. 31, no. 10, 2017, pp. 1495–98.

Chicago Style

Inzaule, S, R Hamers, I Mukui, et al. 2017. “Emergence of Untreatable, Multidrug-Resistant HIV-1 in Patients Failing Second-Line Therapy in Kenya.” AIDS 31 (10): 1495–98.
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Publisher copy:: 10.1097/QAD.0000000000001500

Authors

+ Inzaule, S More by this author

Role:: Author

+ Hamers, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Tropical Medicine
Sub unit:: OUCRU Oxford University Clinical Research Unit
Role:: Author

+ Mukui, I More by this author

Role:: Author

+ Were, K More by this author

Role:: Author

+ Owiti, P More by this author

Role:: Author

More authors...

+ Netherlands Organization for Scientific Research More from this funder

+ Amsterdam Institute for Global Health and Development More from this funder

+ European Union More from this funder

+ Centers for Disease Control and Prevention More from this funder

Publisher:: Lippincott, Williams & Wilkins
Journal:: AIDS More from this journal
Volume:: 31
Issue:: 10
Pages:: 1495–1498
Publication date:: 2017-04-01
Acceptance date:: 2017-03-28
DOI:: 10.1097/QAD.0000000000001500
EISSN:: 1473-5571
ISSN:: 0269-9370

Language:: English
Keywords:: Article in Press
Pubs id:: pubs:699701
UUID:: uuid:7b1242b0-ef0b-411a-bf35-28ea2a2e5634
Local pid:: pubs:699701
Source identifiers:: 699701
Deposit date:: 2017-06-14
ARK identifier:: ark:/29072/ora_7b1242b0ef0b411abf3528ea2a2e5634

Terms of use

Copyright date:: 2017

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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