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Ten quick tips for harnessing the power of ChatGPT in computational biology

Abstract:
The advent of generative AI models holds tremendous potential for aiding teachers in the generation of pedagogical materials. However, numerous knowledge gaps concerning the behavior of these models obfuscate the generation of research-informed guidance for their effective usage. Here we assess trends in prompt specificity, variability, and weaknesses in foreign language teacher lesson plans generated by zero-shot prompting in ChatGPT. Iterating a series of prompts that increased in complexity, we found that output lesson plans were generally high quality, though additional context and specificity to a prompt did not guarantee a concomitant increase in quality. Additionally, we observed extreme cases of variability in outputs generated by the same prompt. In many cases, this variability reflected a conflict between 20th century versus 21st century pedagogical practices. These results suggest that the training of generative AI models on classic texts concerning pedagogical practices may represent a currently underexplored topic with the potential to bias generated content towards teaching practices that have been long refuted by research. Collectively, our results offer immediate translational implications for practicing and training foreign language teachers on the use of AI tools. More broadly, these findings reveal the existence of generative AI output trends that have implications for the generation of pedagogical materials across a diversity of content areas
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1011319

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Role:
Author
ORCID:
0000-0003-2473-2313
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Role:
Author
ORCID:
0000-0002-9416-6145
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Role:
Author
ORCID:
0000-0002-4879-3148
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Role:
Author
ORCID:
0000-0002-7327-4294
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-5264-8368


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Funder identifier:
10.13039/100014989
Grant:
CZI0073
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Funder identifier:
10.13039/501100001807
Grant:
2019/26284-1


Publisher:
Public Library of Science
Journal:
PLoS Computational Biology More from this journal
Volume:
19
Issue:
8
Pages:
e1011319-e1011319
Publication date:
2023-08-10
DOI:
EISSN:
1553-7358
ISSN:
1553-734X


Language:
English
Keywords:
Pubs id:
1511633
Local pid:
pubs:1511633
Source identifiers:
W4385741486
Deposit date:
2026-05-12
ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.

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