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Thesis

Visualising antigen-specific T-cells during primary and persistent infection with Epstein-Barr virus

Abstract:

Cytotoxic T lymphocytes play an important role in mediating host immune reactions to viruses and other pathogens. Selective mechanisms operate during V(D)J recombination to enhance the diversity of the T cell repertoire that is generated, particularly in the CDR3 regions of the TCR, which mediate peptide recognition. The influence of V gene 3' sequences on the composition of the CDR3 loop in TCR β chains is analysed; in particular, A/T-rich coding termini are shown to be more susceptible ...

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Institution:
University of Oxford
Department:
Faculty of Clinical Medicine
Publication date:
1999
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603836129
URN:
uuid:7b015b99-5d24-4c79-b724-dfdb8a03e202
Local pid:
td:603836129
Language:
English
Subjects:

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