Journal article
Current management of xerostomia in head and neck cancer patients
- Abstract:
- Radiotherapy (RT) continues to play a key role in the management of head and neck cancer (HNC). Xerostomia remains a principal detriment to the quality of life (QoL) for 80 % of surviving patients receiving head and neck radiation. Radiation-induced injury to the salivary glands is dose-dependent, and thus efforts have been focused on decreasing radiation to the salivary glands. Decreased saliva production reduces both short-term and long-term quality of life in head and neck survivors by impacting on taste and contributing to dysphagia. Several radioprotective agents to the salivary gland have been investigated. Although not widely practiced, surgical transfer of the submandibular gland prior to RT is the mainstay of surgical options in preventing xerostomia. This review focuses on the strategies to improve xerostomia following radiation therapy in head and neck cancers.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 186.7KB, Terms of use)
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- Publisher copy:
- 10.1016/j.amjoto.2023.103867
Authors
- Publisher:
- Elsevier
- Journal:
- American Journal of Otolaryngology More from this journal
- Volume:
- 44
- Issue:
- 4
- Article number:
- 103867
- Publication date:
- 2023-03-28
- Acceptance date:
- 2023-03-06
- DOI:
- ISSN:
-
0196-0709
- Language:
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English
- Pubs id:
-
1335316
- Local pid:
-
pubs:1335316
- Deposit date:
-
2023-04-01
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2023
- Rights statement:
- © 2023 Elsevier Inc. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at https://dx.doi.org/10.1016/j.amjoto.2023.103867
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