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Plasma membrane segregation during T cell activation: probing the order of domains.

Abstract:

T cell activation leads to a segregation of plasma membrane domains to form TCR signalling clusters and eventually immunological synapses. At these T cell activation sites signalling protein networks reside in plasma membrane regions which adopt a highly ordered physical state. Studies of reconstituted model membranes suggest that aggregation of lipid raft-favouring membrane components may trigger this lipid ordering and condensation of membrane domains in T cells. Activation-induced protein-...

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Publication status:
Published

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Publisher copy:
10.1016/j.coi.2007.05.002

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Rentero, C More by this author
Journal:
Current opinion in immunology
Volume:
19
Issue:
4
Pages:
470-475
Publication date:
2007-08-05
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
URN:
uuid:7af1cd78-9250-40d0-b895-34c5f88d79ff
Source identifiers:
26192
Local pid:
pubs:26192

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