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Reconstructing the ancestral germ line methylation state of young repeats.

Abstract:

One of the key objectives of comparative genomics is the characterization of the forces that shape genomes over the course of evolution. In the last decades, evidence has been accumulated that for vertebrate genomes also epigenetic modifications have to be considered in this context. Especially, the elevated mutation frequency of 5-methylcytosine (5mC) is assumed to facilitate the depletion of CpG dinucleotides in species that exhibit global DNA methylation. For instance, the underrepresentat...

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Publication status:
Published

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Publisher copy:
10.1093/molbev/msr001

Authors


Journal:
Molecular biology and evolution
Volume:
28
Issue:
6
Pages:
1777-1784
Publication date:
2011-06-01
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
Source identifiers:
112494
Language:
English
Keywords:
Pubs id:
pubs:112494
UUID:
uuid:7ada9d99-6bd8-43f3-b030-1196efcdff26
Local pid:
pubs:112494
Deposit date:
2012-12-19

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