OBJECTIVES: HIV-1 p15 Gag and its protease cleavage products, NCp7 and p6, are believed to play a major role in viral infectivity and assembly during the early and late stages of the retroviral life cycle. However, the extent to which p15 Gag is targeted by the host immune system in natural infection as well as precise cytotoxic T lymphocyte (CTL) epitopes within this protein remains to be defined. METHODS: In this study, 57 HIV-1 infected individuals and 10 HIV-1 negative controls were scre...Expand abstract
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Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
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