Journal article
Heterobiaryl synthesis by contractive C-C coupling via P(V) intermediates
- Abstract:
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Heterobiaryls composed of pyridine and diazine rings are key components of pharmaceuticals and are often central to pharmacological function. We present an alternative approach to metal-catalyzed cross-coupling to make heterobiaryls using contractive phosphorus C–C couplings, also termed phosphorus ligand coupling reactions. The process starts by regioselective phosphorus substitution of the C–H bonds para to nitrogen in two successive heterocycles; ligand coupling is then triggered via acidi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 578.1KB, Terms of use)
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- Publisher copy:
- 10.1126/science.aas8961
Authors
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science More from this journal
- Volume:
- 362
- Issue:
- 6416
- Pages:
- 799-804
- Publication date:
- 2018-11-16
- Acceptance date:
- 2018-09-25
- DOI:
- EISSN:
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1095-9203
- ISSN:
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0036-8075
- Pmid:
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30442804
Item Description
- Language:
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English
- Pubs id:
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pubs:943986
- UUID:
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uuid:7acd2824-ee4c-43ab-8a50-bb9989a6f665
- Local pid:
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pubs:943986
- Source identifiers:
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943986
- Deposit date:
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2018-12-28
Terms of use
- Copyright holder:
- Hilton et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors, some rights reserved. This is the accepted manuscript version of the article. The final version is available online from the American Association for the Advancement of Science at: 10.1126/science.aas8961
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