Journal article icon

Journal article

Heterobiaryl synthesis by contractive C-C coupling via P(V) intermediates

Abstract:

Heterobiaryls composed of pyridine and diazine rings are key components of pharmaceuticals and are often central to pharmacological function. We present an alternative approach to metal-catalyzed cross-coupling to make heterobiaryls using contractive phosphorus C–C couplings, also termed phosphorus ligand coupling reactions. The process starts by regioselective phosphorus substitution of the C–H bonds para to nitrogen in two successive heterocycles; ligand coupling is then triggered via acidi...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1126/science.aas8961

Authors


More by this author
ORCID:
0000-0001-5734-3547
More by this author
ORCID:
0000-0002-9360-2179
More by this author
ORCID:
0000-0002-0769-7168
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Subgroup:
Organic Chemistry
Oxford college:
St Hildas College
ORCID:
0000-0002-0104-4166
Expand authors...
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Journal website
Volume:
362
Issue:
6416
Pages:
799-804
Publication date:
2018-11-16
Acceptance date:
2018-09-25
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pubs id:
pubs:943986
URN:
uri:7acd2824-ee4c-43ab-8a50-bb9989a6f665
UUID:
uuid:7acd2824-ee4c-43ab-8a50-bb9989a6f665
Local pid:
pubs:943986
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP