Journal article
The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes
- Abstract:
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Humans exposed to Mycobacterium tuberculosis (Mtb) have variable susceptibility to tuberculosis (TB) and its outcomes. Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains. The SIGLEC14 coding sequence is deleted in a high proportion of individuals, placing a SIGLEC5-like gene under the expression of the SIGLEC14 promoter (the SIGLEC14 null allele) and causing ex...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 347.1KB, Terms of use)
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- Publisher copy:
- 10.1016/j.tube.2017.02.005
Authors
Funding
+ Dana Foundation
More from this funder
Funding agency for:
Hanekom, W
Hawn, T
Grant:
NIHNO1-AI-70022 (Tuberculosis Research Unit
1008461
+ National Institutes of Health
More from this funder
Funding agency for:
Hanekom, W
Graustein, A
Hawn, T
Grant:
NIHNO1-AI-70022 (Tuberculosis Research Unit
NIH5T32HL007287
1008461
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Tuberculosis More from this journal
- Volume:
- 104
- Pages:
- 38-45
- Publication date:
- 2017-02-21
- Acceptance date:
- 2017-02-19
- DOI:
- EISSN:
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1873-281X
- ISSN:
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1472-9792
Item Description
- Keywords:
- Pubs id:
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pubs:686807
- UUID:
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uuid:7a934a8b-36e8-4d9a-b3c8-78952efe7f1a
- Local pid:
-
pubs:686807
- Source identifiers:
-
686807
- Deposit date:
-
2017-04-05
Terms of use
- Copyright holder:
- © 2017 Elsevier Ltd All rights reserved
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Elsevier at: 10.1016/j.tube.2017.02.005
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