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BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

Abstract:

Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PFI-1, and Bromosporine. These molecules target Bromodomain and Extra Terminal domain (BET) proteins, which are epigenetic readers of acetylated histone lysine tail residues. BETi-mediated anti-m...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-06483-7

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Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
Article: 6153
Publication date:
2017-07-21
Acceptance date:
2017-06-14
DOI:
ISSN:
2045-2322
Pubs id:
pubs:709097
URN:
uri:7a58d9db-0788-4e8f-ae14-c613d266f36e
UUID:
uuid:7a58d9db-0788-4e8f-ae14-c613d266f36e
Local pid:
pubs:709097
Paper number:
1
Language:
English

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