- Abstract:
-
Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PFI-1, and Bromosporine. These molecules target Bromodomain and Extra Terminal domain (BET) proteins, which are epigenetic readers of acetylated histone lysine tail residues. BETi-mediated anti-m...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 13.8MB)
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- Publisher copy:
- 10.1038/s41598-017-06483-7
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Issue:
- 1
- Pages:
- Article: 6153
- Publication date:
- 2017-07-21
- Acceptance date:
- 2017-06-14
- DOI:
- ISSN:
-
2045-2322
- Pubs id:
-
pubs:709097
- URN:
-
uri:7a58d9db-0788-4e8f-ae14-c613d266f36e
- UUID:
-
uuid:7a58d9db-0788-4e8f-ae14-c613d266f36e
- Local pid:
- pubs:709097
- Paper number:
- 1
- Language:
- English
- Copyright holder:
- Roberts et al.
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis
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