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The reorganization and reactivation of hippocampal maps predict spatial memory performance.

Abstract:

The hippocampus is an important brain circuit for spatial memory and the spatially selective spiking of hippocampal neuronal assemblies is thought to provide a mnemonic representation of space. We found that remembering newly learnt goal locations required NMDA receptor-dependent stabilization and enhanced reactivation of goal-related hippocampal assemblies. During spatial learning, place-related firing patterns in the CA1, but not CA3, region of the rat hippocampus were reorganized to repres...

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Publication status:
Published

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Publisher copy:
10.1038/nn.2599

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
O'Neill, J More by this author
Pleydell-Bouverie, B More by this author
Csicsvari, J More by this author
Journal:
Nature neuroscience
Volume:
13
Issue:
8
Pages:
995-1002
Publication date:
2010-08-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:7a48c442-78c2-4a1a-b8ec-9845bd870c21
Source identifiers:
329229
Local pid:
pubs:329229

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