Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells.

Journal article

Tumor necrosis factor-alpha (TNF-alpha) plays a critical role in the control of endothelial cell function and hence in regulating traffic of circulating cells into tissues in vivo. Stimulation of endothelial cells in vitro by TNF-alpha increases the surface expression of leukocyte adhesion molecules, enhances cytokine production, and induces tissue factor procoagulant activity. In the present study, we have examined the relative roles of the two cell surface receptors for TNF-alpha (p55 and p...

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Authors: Paleolog, E; Delasalle, SA; Buurman, W; Feldmann, M

• Publication status: Published
• Journal: Blood
• Volume: 84
• Issue: 8
• Pages: 2578-2590
• Publication date: 1994-10-01
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Necrosis Factor-alpha; Endothelium, Vascular; Antigens, CD31; Antibodies; Thromboplastin; Humans; Lymphotoxin-alpha; Receptors, Tumor Necrosis Factor; Cell Adhesion Molecules; Umbilical Veins; Interleukin-8; Cell Division; Cross-Linking Reagents; Antigens, Differentiation, Myelomonocytic