Diagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis—Systematic Review

Journal article

A range of molecular amplification techniques has been developed for the diagnosis of HAT, with polymerase chain reaction (PCR) at the forefront. As laboratory strengthening in endemic areas increases, it is expected that the applicability of molecular tests will increase. However, careful evaluation of these tests against the current reference standard, microscopy, must precede implementation. Therefore, we have investigated the published diagnostic accuracy of molecular amplification tests for HAT compared to microscopy for both initial diagnosis as well as for disease staging

Authors: Mugasa, CM; Adams, ER; Boer, KR; Dyserinck, HC; Büscher, P

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS Neglected Tropical Diseases
• Volume: 6
• Issue: 1
• Pages: e1438-e1438
• Publication date: 2012-01-10
• DOI: 10.1371/journal.pntd.0001438
• EISSN: 1935-2735
• ISSN: 1935-2727
• Language: English
• Keywords: Meta-analysis; Medicine; Internal medicine; Bivariate analysis; Veterinary medicine; Diagnostic accuracy; Statistics; Biology; Population; Diagnostic test; Mathematics; Pathology