Journal article
Exposing the exposures responsible for type 2 diabetes and obesity
- Abstract:
- The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although “Western” lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 170.2KB, Terms of use)
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(Accepted manuscript, jpeg, 84.4KB, Terms of use)
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(Accepted manuscript, jpeg, 122.5KB, Terms of use)
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(Accepted manuscript, jpeg, 56.3KB, Terms of use)
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(Accepted manuscript, jpeg, 108.0KB, Terms of use)
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- Publisher copy:
- 10.1126/science.aaf5094
Authors
+ National Institutes of Health
More from this funder
- Funding agency for:
- McCarthy, M
- Grant:
- DK098032
- DK105535
+ European Commission
More from this funder
- Funding agency for:
- McCarthy, M
- Grant:
- DK105535
- DK098032
+ Medical Research Council
More from this funder
- Funding agency for:
- McCarthy, M
- Grant:
- DK098032
- DK105535
- Publisher:
- American Association for the Advancement of Science
- Journal:
- Science More from this journal
- Volume:
- 354
- Issue:
- 6308
- Pages:
- 69-73
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-09-01
- DOI:
- EISSN:
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1095-9203
- ISSN:
-
0036-8075
- Pubs id:
-
pubs:652690
- UUID:
-
uuid:7a2cdfc1-3c56-4ffb-91a4-2df62394712b
- Local pid:
-
pubs:652690
- Source identifiers:
-
652690
- Deposit date:
-
2016-10-16
- ARK identifier:
Terms of use
- Copyright holder:
- Franks and McCarthy
- Copyright date:
- 2016
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: http://dx.doi.org/10.1126/science.aaf5094
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