Advances in tenascin-C biology.

Journal article

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

Authors: Midwood, K; Hussenet, T; Langlois, B; Orend, G

• Journal: Cellular and molecular life sciences : CMLS More from this journal
• Volume: 68
• Issue: 19
• Pages: 3175-3199
• Publication date: 2011-10-01
• DOI: 10.1007/s00018-011-0783-6
• EISSN: 1420-9071
• ISSN: 1420-682X
• Language: English
• Keywords: Gene Expression Regulation; Mice; Rats; Vascular Diseases; Myocardial Infarction; Humans; Neovascularization, Pathologic; Animals; Atherosclerosis; Tenascin; Neoplasms; Neoplastic Stem Cells; Wound Healing; Myocytes, Smooth Muscle; Stem Cells; Myocardium