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Oxidative activity of hydroxylated primaquine analogs. Non-toxicity to glucose-6-phosphate dehydrogenase-deficient human red blood cells in vitro.

Abstract:

The individual effects of two putative metabolites of primaquine (5,6-dihydroxyprimaquine and 5,6-dihydroxy-8-aminoquinoline) on the hexose monophosphate shunt (HMS) and on the ATP-dependent proteolytic system which rapidly degrades oxidized erythrocyte protein were measured in intact red blood cells in vitro from two blood donors. In red cells treated with nitrite (1-40 mM) or phenylhydrazine (0.01-10 mM), proteolytic activity was detected only with concentrations (7.5 mM NaNO2 and 0.25 mM p...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
Journal:
Biochemical pharmacology
Volume:
35
Issue:
7
Pages:
1091-1098
Publication date:
1986-04-05
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
URN:
uuid:7a1e92ca-f6ec-41c6-9b62-815a16f86673
Source identifiers:
81620
Local pid:
pubs:81620

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