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The dynamics of lysozyme from bacteriophage lambda in solution probed by NMR and MD simulations.

Abstract:

(15) N NMR relaxation studies, analyses of NMR data to include chemical shifts, residual dipolar couplings (RDC), NOEs and H(N) -H(α) coupling constants, and molecular dynamics (MD) simulations have been used to characterise the behaviour of lysozyme from bacteriophage lambda (λ lysozyme) in solution. The lower and upper lip regions in λ lysozyme (residues 51-60 and 128-141, respectively) show reduced (1) H-(15) N order parameters indicating mobility on a picosecond timescale. In addition, re...

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Publication status:
Published

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Publisher copy:
10.1002/cbic.201300193

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
Chembiochem : a European journal of chemical biology
Volume:
14
Issue:
14
Pages:
1780-1788
Publication date:
2013-09-05
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
URN:
uuid:7a0f8029-052a-41d4-87fc-e9d5342073c7
Source identifiers:
407814
Local pid:
pubs:407814

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