Journal article
The COMET Handbook: version 1.0.
- Abstract:
- The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to influence policy and practice, the outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. It is now widely acknowledged that insufficient attention has been paid to the choice of outcomes measured in clinical trials. Researchers are increasingly addressing this issue through the development and use of a core outcome set, an agreed standardised collection of outcomes which should be measured and reported, as a minimum, in all trials for a specific clinical area.Accumulating work in this area has identified the need for guidance on the development, implementation, evaluation and updating of core outcome sets. This Handbook, developed by the COMET Initiative, brings together current thinking and methodological research regarding those issues. We recommend a four-step process to develop a core outcome set. The aim is to update the contents of the Handbook as further research is identified.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1186/s13063-017-1978-4
Authors
- Publisher:
- BioMed Central
- Journal:
- Trials More from this journal
- Volume:
- 18
- Issue:
- Suppl 3
- Pages:
- 280
- Publication date:
- 2017-06-01
- Acceptance date:
- 2017-05-02
- DOI:
- ISSN:
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1745-6215
- Language:
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English
- Keywords:
- Pubs id:
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pubs:703140
- UUID:
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uuid:79c23bfc-0650-4eb1-aa70-5048dfeb7fa9
- Local pid:
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pubs:703140
- Source identifiers:
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703140
- Deposit date:
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2017-07-10
Terms of use
- Copyright holder:
- Clarke et al
- Copyright date:
- 2017
- Notes:
- © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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