Journal article
Immunotherapy-resistant neuropathic pain and fatigue predict quality-of-life in contactin-associated protein-like 2 antibody disease
- Abstract:
- The long-term clinical outcomes and associated prognostic factors in contactin-associated protein-like 2 (CASPR2)-antibody diseases are unknown. A total of 75 participants with CASPR2 antibodies were longitudinally assessed for disability, quality-of-life, and chronic pain. Although most symptoms improved within 6 months of treatment, neuropathic pain and fatigue were the most immunotherapy refractory, and persisted for up to 6 years. Furthermore, these two factors—but not CASPR2 antibody levels or subclasses—independently predicted worse disability and quality-of-life at 24 months. Quality-of-life varied widely for any given modified Rankin Scale score, indicating a divergence between patient and clinician assessed outcomes. Further work should study the relative importance of these measures, and the immunopathogenesis underlying intractable symptoms. ANN NEUROL 2025
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 2.2MB, Terms of use)
-
- Publisher copy:
- 10.1002/ana.27177
Authors
+ Royal Society
More from this funder
- Funder identifier:
- https://ror.org/03wnrjx87
- Grant:
- IES\R3\213098
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 104079/Z/14/Z
- 102176/Z/13/Z
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/V007173/1
- MR/X022013/1
+ National Institute for Health Research
More from this funder
- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- BRCRCF19-04
- Publisher:
- Wiley
- Journal:
- Annals of Neurology More from this journal
- Volume:
- 97
- Issue:
- 3
- Pages:
- 521-528
- Publication date:
- 2025-01-18
- Acceptance date:
- 2024-12-20
- DOI:
- EISSN:
-
1531-8249
- ISSN:
-
0364-5134
- Language:
-
English
- Pubs id:
-
2072296
- Local pid:
-
pubs:2072296
- Deposit date:
-
2024-12-24
Terms of use
- Copyright holder:
- Ceronie et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record