Journal article
Systematic review protocol: an assessment of the post-approval challenges of autologous CAR-T therapy delivery
- Abstract:
- Following recent regulatory approvals of two chimeric antigen receptor T-cell (CAR-T) therapies, the field now faces a number of post-approval challenges. These challenges are in some respects defined and, in others, uncertain due to the nascence of the field. At present, information pertaining to such post-approval challenges are scattered in various previous reviews or raised in singular papers reporting experience in working with the therapy. This systematic review is designed to evaluate and summarise the post-approval challenges for robust delivery of CAR-T therapies to inform future work on the optimisation of CAR-T delivery to patients.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 621.6KB, Terms of use)
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- Publisher copy:
- 10.1136/bmjopen-2018-026172
Authors
- Publisher:
- BMJ Journals
- Journal:
- BMJ Open More from this journal
- Volume:
- 9
- Issue:
- 7
- Pages:
- Article:e026172
- Publication date:
- 2019-07-04
- Acceptance date:
- 2019-06-05
- DOI:
- ISSN:
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2044-6055
- Pubs id:
-
pubs:1008950
- UUID:
-
uuid:799bfee3-b74e-4a15-9ab8-5479fe12850c
- Local pid:
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pubs:1008950
- Source identifiers:
-
1008950
- Deposit date:
-
2019-06-06
Terms of use
- Copyright holder:
- Lam et al
- Copyright date:
- 2019
- Notes:
- © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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