Journal article
SARS-CoV-2 genomic diversity and within-host evolution in individuals with persistent infection in the UK: an observational, longitudinal, population-based surveillance study
- Abstract:
-
Background
Persistent SARS-CoV-2 infections in hospitalised immunocompromised individuals are known to facilitate accelerated within-host viral evolution, potentially contributing to the emergence of highly divergent variants. However, little is known about the evolutionary dynamics and transmission risks of persistent infections in the general population. We aimed to characterise the within-host evolution of SARS-CoV-2 during persistent infections identified through a la... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 15.5MB, Terms of use)
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- Publisher copy:
- 10.1016/j.lanmic.2025.101154
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 107652/Z/15/Z
- 227438/Z/23/Z
- 203141/Z/16/Z
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MC_PC_19027
+ National Institute for Health and Care Excellence
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- Funder identifier:
- https://ror.org/015ah0c92
- Grant:
- NIHR200915
+ Department of Health and Social Care
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- Funder identifier:
- https://ror.org/03sbpja79
- Publisher:
- Elsevier
- Journal:
- Lancet Microbe More from this journal
- Volume:
- 6
- Issue:
- 9
- Article number:
- 101154
- Publication date:
- 2025-07-30
- Acceptance date:
- 2025-04-23
- DOI:
- EISSN:
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2666-5247
- Language:
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English
- Pubs id:
-
2120451
- Local pid:
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pubs:2120451
- Deposit date:
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2025-04-29
- ARK identifier:
Terms of use
- Copyright holder:
- Ghafari et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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