Journal article
Defining the structural relationship between kainate-receptor deactivation and desensitization.
- Abstract:
-
Desensitization is an important mechanism curtailing the activity of ligand-gated ion channels (LGICs). Although the structural basis of desensitization is not fully resolved, it is thought to be governed by physicochemical properties of bound ligands. Here, we show the importance of an allosteric cation-binding pocket in controlling transitions between activated and desensitized states of rat kainate-type (KAR) ionotropic glutamate receptors (iGluRs). Tethering a positive charge to this pock...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nsmb.2654
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Authors
Bibliographic Details
- Journal:
- Nature structural and molecular biology
- Volume:
- 20
- Issue:
- 9
- Pages:
- 1054-1061
- Publication date:
- 2013-09-01
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Source identifiers:
-
418507
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:418507
- UUID:
-
uuid:798949c7-8690-4957-8ca6-617e209c65f4
- Local pid:
- pubs:418507
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2013
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