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Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso.

Abstract:

OBJECTIVES: Mefloquine/artesunate has recently been developed as a fixed-dose combination, providing a promising rescue/alternative treatment for malaria during pregnancy. However, limited data are available on the effect of pregnancy on its pharmacokinetic properties. This study was conducted to assess the pharmacokinetic properties of mefloquine/carboxymefloquine and artesunate/dihydroartemisinin in pregnant and non-pregnant women with uncomplicated malaria. METHODS: Twenty-four women in th...

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Publication status:
Published

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Publisher copy:
10.1093/jac/dku154

Authors


Traore-Coulibaly, M More by this author
Lindegardh, N More by this author
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Publisher:
Oxford University Press
Journal:
The Journal of antimicrobial chemotherapy
Volume:
69
Issue:
9
Pages:
2499-2507
Publication date:
2014-09-05
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
URN:
uuid:798624b9-f113-43a2-93f1-917c7e815d96
Source identifiers:
469063
Local pid:
pubs:469063
Language:
English
Keywords:

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