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Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment

Abstract:

Tumour necrosis factor (TNF) is produced by primary human macrophages in response to stimulation by exogenous pathogen-associated molecular patterns (PAMPs) and endogenously generated damage-associated molecular patterns (DAMPs) via Toll-like receptor (TLR) signalling. However, uncontrolled TNF production can be deleterious and hence it is tightly controlled at multiple stages. We have previously shown that Bruton’s tyrosine kinase (Btk) regulates TLR4-induced TNF production via p38 MAP Kinas...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bbrc.2018.03.140

Authors


Urbaniak, AM More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS; KIR
Smallie, T More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Biochemical and Biophysical Research Communications Journal website
Volume:
499
Issue:
2
Pages:
260-266
Publication date:
2018-03-22
Acceptance date:
2018-03-19
DOI:
ISSN:
0006-291X
Pubs id:
pubs:830315
URN:
uri:798039a7-c58a-4f06-91ec-94ec97d44e41
UUID:
uuid:798039a7-c58a-4f06-91ec-94ec97d44e41
Local pid:
pubs:830315

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