Journal article
Bruton's tyrosine kinase regulates TLR7/8-induced TNF transcription via nuclear factor-κB recruitment
- Abstract:
-
Tumour necrosis factor (TNF) is produced by primary human macrophages in response to stimulation by exogenous pathogen-associated molecular patterns (PAMPs) and endogenously generated damage-associated molecular patterns (DAMPs) via Toll-like receptor (TLR) signalling. However, uncontrolled TNF production can be deleterious and hence it is tightly controlled at multiple stages. We have previously shown that Bruton’s tyrosine kinase (Btk) regulates TLR4-induced TNF production via p38 MAP Kinas...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 1.4MB)
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- Publisher copy:
- 10.1016/j.bbrc.2018.03.140
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Biochemical and Biophysical Research Communications Journal website
- Volume:
- 499
- Issue:
- 2
- Pages:
- 260-266
- Publication date:
- 2018-03-22
- Acceptance date:
- 2018-03-19
- DOI:
- ISSN:
-
0006-291X
- Pubs id:
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pubs:830315
- URN:
-
uri:798039a7-c58a-4f06-91ec-94ec97d44e41
- UUID:
-
uuid:798039a7-c58a-4f06-91ec-94ec97d44e41
- Local pid:
- pubs:830315
- Paper number:
- 2
Item Description
Terms of use
- Copyright holder:
- Page et al.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4
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