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Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.

Abstract:

The adenoma:carcinoma sequence is well established. Understanding the molecular pathology of the adenoma is therefore important. There is great controversy within the field. The Vogelstein group champions the "top-down" theory (colorectal adenomas arise and grow across the mucosal surface and down into the crypts), whereas other studies, including our own, propose "bottom-up" spread. Serial sections of 40 small (<3 mm) sporadic colorectal adenomas were stained with HandE, MIB-1, and for be...

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Publication status:
Published

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Journal:
Cancer research
Volume:
63
Issue:
13
Pages:
3819-3825
Publication date:
2003-07-05
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:79765f87-aad1-44c8-9b26-ce2267b472c3
Source identifiers:
72215
Local pid:
pubs:72215

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