Journal article
Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission.
- Abstract:
-
The adenoma:carcinoma sequence is well established. Understanding the molecular pathology of the adenoma is therefore important. There is great controversy within the field. The Vogelstein group champions the "top-down" theory (colorectal adenomas arise and grow across the mucosal surface and down into the crypts), whereas other studies, including our own, propose "bottom-up" spread. Serial sections of 40 small (<3 mm) sporadic colorectal adenomas were stained with HandE, MIB-1, and for be...
Expand abstract
- Publication status:
- Published
Actions
Authors
Bibliographic Details
- Journal:
- Cancer research
- Volume:
- 63
- Issue:
- 13
- Pages:
- 3819-3825
- Publication date:
- 2003-07-01
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
72215
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:72215
- UUID:
-
uuid:79765f87-aad1-44c8-9b26-ce2267b472c3
- Local pid:
- pubs:72215
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2003
If you are the owner of this record, you can report an update to it here: Report update to this record