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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes

Abstract:

Background: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. R...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s11689-016-9157-6

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Pettigrew, KA More by this author
Frinton, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Grant:
097831/Z/11/Z; WT082032MA; 090532/Z/09/Z
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Publisher:
BioMed Central Publisher's website
Journal:
Journal of Neurodevelopmental Disorders Journal website
Publication date:
2016-06-14
DOI:
EISSN:
1866-1955
ISSN:
1866-1947
URN:
uuid:79663258-559d-4179-98e1-ba0214db9238
Source identifiers:
626325
Local pid:
pubs:626325

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