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Hydroxycarbamide plus Aspirin vs Aspirin alone in patients with essential Thrombocythaemia aged 40-59 years without high-risk features

Abstract:
Purpose: Cytoreductive therapy is beneficial in patients with essential thrombocythemia at high risk of thrombosis. However its value in those lacking high-risk features remains unknown. This open-label, randomized trial compared hydroxycarbamide plus aspirin with aspirin alone in patients with ET aged 40- 59 and without high-risk factors or extreme thrombocytosis. Methods: Patients were aged 40-59 years and lacked a history of ischemia, thrombosis, embolis... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1200/JCO.2018.78.8414

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0001-5909-4265
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Medical Research Council More from this funder
Cancer Research UK More from this funder
Leukemia and Lymphoma Society of America More from this funder
French National Cancer Institute More from this funder
Kay Kendall Leukaemia Fund More from this funder
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Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Volume:
36
Issue:
34
Pages:
3361-3369
Publication date:
2018-08-28
Acceptance date:
2018-06-29
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
Source identifiers:
859742
Pubs id:
pubs:859742
UUID:
uuid:7965991e-66aa-47b4-8113-00aeb1d3dc87
Local pid:
pubs:859742
Deposit date:
2018-06-29

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