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Hydroxycarbamide plus Aspirin vs Aspirin alone in patients with essential Thrombocythaemia aged 40-59 years without high-risk features

Abstract:
Purpose: Cytoreductive therapy is beneficial in patients with essential thrombocythemia at high risk of thrombosis. However its value in those lacking high-risk features remains unknown. This open-label, randomized trial compared hydroxycarbamide plus aspirin with aspirin alone in patients with ET aged 40- 59 and without high-risk factors or extreme thrombocytosis. Methods: Patients were aged 40-59 years and lacked a history of ischemia, thrombosis, embolis... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1200/JCO.2018.78.8414

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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Population Health
Role:
Author
ORCID:
0000-0001-5909-4265
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Medical Research Council More from this funder
Cancer Research UK More from this funder
French National Cancer Institute More from this funder
Wellcome Trust More from this funder
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Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Volume:
36
Issue:
34
Pages:
3361-3369
Publication date:
2018-08-28
Acceptance date:
2018-06-29
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
Pubs id:
pubs:859742
URN:
uri:7965991e-66aa-47b4-8113-00aeb1d3dc87
UUID:
uuid:7965991e-66aa-47b4-8113-00aeb1d3dc87
Local pid:
pubs:859742

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