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The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

Abstract:

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of monoamine neurotransmitters, the generation of nitric oxide, and pain1,2. Here we uncover a link between these processes, identifying a fundamental role for BH4 in T cell biology. We find that genetic inactivation of GTP cyclohydrolase 1 (GCH1, the rate-limiting enzyme in the synthesis of BH4) and inhibition of sepi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41586-018-0701-2

Authors


Cronin, SJF More by this author
Weidinger, A More by this author
Reissig, S More by this author
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Funding agency for:
Rangachari, M
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Funding agency for:
Penninger, JM
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
563
Pages:
564–568
Publication date:
2018-11-07
Acceptance date:
2018-09-20
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:940205
URN:
uri:7947e425-80f0-412d-ae70-1697db080777
UUID:
uuid:7947e425-80f0-412d-ae70-1697db080777
Local pid:
pubs:940205
Language:
English
Keywords:

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