Chemoenzymatic approaches to plant natural product inspired compounds

Journal article

Complex molecules produced by plants have provided us with a range of medicines, flavour and fragrance compounds and pesticides. However, there are challenges associated with accessing these in an economically viable manner, including low natural abundance and the requirement for complex multi-step synthetic strategies. Chemoenzymatic approaches provide a valuable alternative strategy by combining traditional synthetic methods with biocatalysis. This review highlights recent chemoenzymatic syntheses towards plant natural products and analogues, focusing on the advantages of incorporating biocatalysts into a synthetic strategy

Authors: Roddan, R; Carter, EM; Thair, B; Hailes, HC

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Royal Society of Chemistry
• Journal: Natural Product Reports
• Volume: 39
• Issue: 7
• Pages: 1375-1382
• Publication date: 2022-07-20
• DOI: 10.1039/d2np00008c
• EISSN: 1460-4752
• ISSN: 0265-0568
• Language: English
• Keywords: Mathematics; Natural product; Computer science; Natural (archaeology); Combinatorial chemistry; Biochemical engineering; Product (mathematics); Biochemistry; Chemistry; Computational biology; Engineering; Biology