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Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice

Abstract:

Genome-wide association studies have linked polymorphisms in the autophagy gene ATG16L1 with susceptibility to inflammatory bowel disease (IBD). However, the cell-type-specific effects of autophagy on the regulation of chronic intestinal inflammation have not been investigated. Here, we assessed the effect of myeloid-specific or intestinal epithelial cell (IEC)-specific deletion of Atg16l1 on chronic colitis triggered by the intestinal opportunistic pathogen Helicobacter hepaticus in mice. Al...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.chom.2017.12.017

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0003-4439-725X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Oriel College
Role:
Author
More from this funder
Grant:
MR/K011898/1; MR/N02379X/1
More from this funder
Grant:
107457; 102972; 097112
More from this funder
Grant:
MR/N02379X/1
Publisher:
Cell Press Publisher's website
Journal:
Cell Host and Microbe Journal website
Volume:
23
Issue:
2
Pages:
191-202.e4
Publication date:
2018-01-18
Acceptance date:
2017-12-22
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Pubs id:
pubs:821477
URN:
uri:7891b027-53b5-4b13-aa20-5d6fb5a5d3b2
UUID:
uuid:7891b027-53b5-4b13-aa20-5d6fb5a5d3b2
Local pid:
pubs:821477
Paper number:
2

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