Ca2+ and synaptic plasticity

Journal article

The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell. The Ca2+ signals within these compartments are generated by voltage or ligand-gated Ca2+ influx, and release from intracellular stores. The changes in [Ca2+]i are directly linked to the activity of the neurone, thus a neurone's input and output is translated into a dynamic Ca2+ code. Despite considerable progress in measuring this code much still remains to be determined in order to understand how the code is interpreted by the Ca2+ sensors that underlie the induction of compartment-specific plastic changes. © 2005 Published by Elsevier Ltd.

Authors: Cavazzini, M; Bliss, T; Emptage, N

• Journal: Cell Calcium
• Volume: 38
• Issue: 3-4 SPEC. ISS.
• Pages: 355-367
• Publication date: 2005-09-01
• DOI: 10.1016/j.ceca.2005.06.013
• ISSN: 0143-4160
• Language: English
• Keywords: Calcium Signaling; Inositol 1,4,5-Trisphosphate; Dendrites; Voltage-gated channels; Ryanodine; Calcium; Neuronal Plasticity; Synapses; Long-Term Depression; Receptors, N-Methyl-d-Aspartate; Long-Term Potentiation; Endoplasmic Reticulum; Hippocampus