A linkage map of the rat genome derived from three F2 crosses.

Journal article

We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

Authors: Bihoreau, M; Gauguier, D; Kato, N; Hyne, G; Lindpaintner, K

• Publication status: Published
• Journal: Genome research
• Volume: 7
• Issue: 5
• Pages: 434-440
• Publication date: 1997-05-01
• EISSN: 1549-5469
• ISSN: 1088-9051
• Language: English
• Keywords: Polymorphism, Genetic; Rats; Genetic Linkage; Polymerase Chain Reaction; Rats, Inbred Strains; Crosses, Genetic; Genetic Markers; Rats, Wistar; Rats, Inbred SHR; Genetics, Population; Genetic Variation; Animals; X Chromosome; Rats, Inbred WKY; Chromosome Mapping; Microsatellite Repeats